PAX8-mediated activation of the wt1 tumor suppressor gene.
نویسندگان
چکیده
منابع مشابه
The Wilms’ Tumor Suppressor Wt1 Promotes Cell Adhesion Trhough Transcriptional Activation of the Α4integrin Gene
THE WILMS’ TUMOR SUPPRESSOR WT1 PROMOTES CELL ADHESION TRHOUGH TRANSCRIPTIONAL ACTIVATION OF THE α4INTEGRIN GENE Karin M. Kirschner, Nicole Wagner, Kay-Dietrich Wagner, Sven Wellmann, and Holger Scholz From the Institut für Vegetative Physiologie, Charité – Universitätsmedizin Berlin, Tucholskystrasse 2, 10117 Berlin, Germany, INSERM U636, Centre de Biochimie, Faculté des Sciences, Parc Valrose...
متن کاملThe Wilms' tumor suppressor gene (wt1) product represses different functional classes of transcriptional activation domains.
We have studied the ability of the wt1 tumor suppressor gene product to repress different classes of activation domains previously shown to stimulate the initiation and elongation steps of RNA polymerase II transcription in vivo. Repression assays revealed that WT1 represses all three classes of activation domains: Sp1 and CTF, which stimulate initiation (type I), human immunodeficiency virus t...
متن کاملRole of the WT1 tumor suppressor in murine hematopoiesis.
The WT1 tumor-suppressor gene is expressed by many forms of acute myeloid leukemia. Inhibition of this expression can lead to the differentiation and reduced growth of leukemia cells and cell lines, suggesting that WT1 participates in regulating the proliferation of leukemic cells. However, the role of WT1 in normal hematopoiesis is not well understood. To investigate this question, we have use...
متن کاملNew insights into the function of the Wilms tumor suppressor gene WT1 in podocytes.
The Wilms tumor suppressor gene WT1 is essential for early urogenital development: homozygous mutations in WT1 result in embryonic lethality due to a failure in the development of kidneys and gonads. In the adult kidney, WT1 expression is limited to the glomerular podocytes. Several human nephrotic diseases arise from mutations of the WT1 gene, including mutations that affect its zinc-fingers a...
متن کاملThe Wilms tumor suppressor gene wt1 is required for development of the spleen
The Wilms tumor suppressor gene WT1 (wt1 in mouse) is unique among tumor suppressors because, in addition to its involvement in cancer [1] [2] and various other diseases [3] [4] [5] [6], it has an essential role in the development of certain organs. This is revealed by the phenotype of mice with inactivated wt1 alleles [7]. These animals exhibit a complete failure of kidney and gonad developmen...
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ژورنال
عنوان ژورنال: The EMBO Journal
سال: 1996
ISSN: 0261-4189
DOI: 10.1002/j.1460-2075.1996.tb00804.x